CETUXIMAB IN COMBINATION WITH IRINOTECAN/5-FLUOROURACIL/FOLINIC ACID (FOLFIRI) IN THE INITIAL TREATMENT OF METASTATIC COLORECTAL CANCER: A MULTICENTRE TWO-PART PHASE I/II STUDY

Abstract Background This study was designed to investigate the efficacy and safety of the epidermal growth factor receptor (EGFR) inhibitor cetuximab combined with irinotecan, folinic acid (FA) and two different doses of infusional 5-fluorouracil (5-FU) in the first-line treatment of EGFR-detectable metastatic colorectal cancer.Methods The 5-FU dos

This paper analyzes past experiences Womens Bucket hats and examples of good practice in the development of rural tourism, with particular reference to the potential of Serbia.The aim of this paper is multiple.Given that rural areas in Serbia face significant economic and demographic problems, rural tourism may be one of the answers to the question

Virtual reality users are susceptible to disorientation, particularly when using locomotion interfaces that lack self-motion cues.Environmental cues, such as boundaries defined by walls or a fence, provide information to help the user remain oriented.This experiment evaluated whether the type of boundary impacts its usefulness for staying oriented.

BackgroundCupriavidus necator JMP134 is a Gram-negative beta-proteobacterium able to grow on a variety of aromatic and chloroaromatic compounds as its sole carbon and energy source.Methodology/principal findingsIts genome consists of four replicons (two chromosomes and two plasmids) containing a total of 6631 protein coding genes.Comparative analys

Abstract Background Evidence suggests appearance of socioeconomic gradient in the probability of low birth weight Organization (LBW).Such evidence, however, is scanty in Ethiopia.The study aimed to examine the prevalence of and socioeconomic gradient in LBW in Ethiopia.Method Data for the study were drawn from the Ethiopia Demographic and Health Su